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Target Snapshot

CHEMBL2749 Target Snapshot

Platelet-derived growth factor receptor beta · SINGLE PROTEIN · Mus musculus

458Compounds
26Assays
1Approved Drugs
479.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P05622. Use UniProt P05622 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P05622 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Platelet-derived growth factor receptor beta as ChEMBL target CHEMBL2749, mapped to UniProt P05622. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Platelet-derived growth factor receptor beta
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2749
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P05622
Platelet-derived growth factor receptor beta
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Platelet-derived growth factor receptor beta is the right protein anchor across sources, using UniProt P05622 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPlatelet-derived growth factor receptor beta
UniProt AccessionP05622
Component TypeProtein
Sequence Length1098 aa

Platelet-derived growth factor receptor beta

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Platelet-derived growth factor receptor beta, mapped to UniProt P05622. Sequence length is 1098 aa.

Mapped IDP05622
Review namePlatelet-derived growth factor receptor beta
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC50479.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3109343 9.0 IC50 1.0 Preclinical
CHEMBL3109350 9.0 IC50 1.0 Preclinical
CHEMBL2037208 8.7 IC50 2.0 Preclinical
CHEMBL3109347 8.7 IC50 2.0 Preclinical
CHEMBL3109337 8.52 IC50 3.0 Preclinical
CHEMBL3109338 8.52 IC50 3.0 Preclinical
CHEMBL3109340 8.52 IC50 3.0 Preclinical
CHEMBL3109346 8.52 IC50 3.0 Preclinical
CHEMBL3109356 8.4 IC50 4.0 Preclinical
CHEMBL3109344 8.3 IC50 5.0 Preclinical
Distribution

pChEMBL Value Distribution

66
5.0
61
5.5
71
6.0
41
6.5
30
7.0
9
7.5
6
8.0
6
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

IMATINIB
CHEMBL941
Approved 2001
Assay Landscape

Assay Landscape

26
Total Assays
335
Tested Compounds
2
Assay Types
Binding — 25 assays, 335 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 198 6.0
cell-based format 9 73 6.1
assay format 3 64 5.6
Functional — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 2 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine