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Target Snapshot

CHEMBL2756 Target Snapshot

Amine oxidase [flavin-containing] B · SINGLE PROTEIN · Bos taurus

566Compounds
94Assays
5Approved Drugs
428.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P56560. Use UniProt P56560 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P56560 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Amine oxidase [flavin-containing] B as ChEMBL target CHEMBL2756, mapped to UniProt P56560. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Amine oxidase [flavin-containing] B
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL2756
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P56560
Amine oxidase [flavin-containing] B
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Amine oxidase [flavin-containing] B is the right protein anchor across sources, using UniProt P56560 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAmine oxidase [flavin-containing] B
UniProt AccessionP56560
Component TypeProtein
Sequence Length520 aa

Amine oxidase [flavin-containing] B

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Amine oxidase [flavin-containing] B, mapped to UniProt P56560. Sequence length is 520 aa.

Mapped IDP56560
Review nameAmine oxidase [flavin-containing] B
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

5
Approved
1
Phase III
3
Phase II
Assay Mix

Activity Type Distribution

IC50131.0
KI297.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL385117 9.09 Ki 0.8128 Preclinical
CHEMBL224562 9.0 Ki 1.0 Preclinical
CHEMBL424940 9.0 IC50 1.0 Preclinical
CHEMBL220548 8.88 Ki 1.318 Preclinical
CHEMBL459336 8.82 Ki 1.5 Preclinical
CHEMBL2096866 8.57 Ki 2.7 Preclinical
CHEMBL375007 8.39 Ki 4.074 Preclinical
CHEMBL218059 8.22 IC50 6.026 Preclinical
CHEMBL387736 8.22 Ki 6.0 Preclinical
CHEMBL385124 8.15 Ki 7.079 Preclinical
Distribution

pChEMBL Value Distribution

26
5.0
26
5.5
59
6.0
15
6.5
10
7.0
20
7.5
9
8.0
4
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELEGILINE
CHEMBL972
Approved 1989
Assay Landscape

Assay Landscape

94
Total Assays
371
Tested Compounds
1
Assay Types
Binding — 94 assays, 371 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 50 70 5.0
assay format 31 151 5.9
mitochondrion format 12 149 6.2
tissue-based format 1 1 7.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine