Sphingomyelin phosphodiesterase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P17405. Use UniProt P17405 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P17405 as the stable identity anchor, then attach disease evidence before program review.
Sphingomyelin phosphodiesterase
Review this target as Sphingomyelin phosphodiesterase, mapped to UniProt P17405. Sequence length is 631 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sphingomyelin phosphodiesterase as ChEMBL target CHEMBL2760, mapped to UniProt P17405. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Sphingomyelin phosphodiesterase is the right protein anchor across sources, using UniProt P17405 as the stable mapping.
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| Preferred Name | Sphingomyelin phosphodiesterase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P17405 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sphingomyelin phosphodiesterase |
| UniProt Accession | P17405 |
| Component Type | Protein |
| Sequence Length | 631 aa |
Sphingomyelin phosphodiesterase
Review this target as Sphingomyelin phosphodiesterase, mapped to UniProt P17405. Sequence length is 631 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4163007 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL4553570 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL5288063 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL4176817 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL4167088 | 6.54 | IC50 | 290.0 | Preclinical |
| CHEMBL4161092 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL5434322 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL4172326 | 6.51 | IC50 | 310.0 | Preclinical |
| CHEMBL4551503 | 6.5 | IC50 | 320.0 | Preclinical |
| CHEMBL4464117 | 6.47 | IC50 | 340.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 27 | 101 | 5.3 |
| cell-based format | 8 | 0 | — |
| assay format | 4 | 49 | 5.1 |
| cell membrane format | 1 | 1 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |