Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL2781 Target Snapshot

Sodium/hydrogen exchanger 1 · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
346Compounds
36Assays
1Approved Drugs
450.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P19634. Use UniProt P19634 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P19634 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium/hydrogen exchanger 1 as ChEMBL target CHEMBL2781, mapped to UniProt P19634. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium/hydrogen exchanger 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2781
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P19634
Sodium/hydrogen exchanger 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium/hydrogen exchanger 1 is the right protein anchor across sources, using UniProt P19634 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSodium/hydrogen exchanger 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP19634
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium/hydrogen exchanger 1
UniProt AccessionP19634
Component TypeProtein
Sequence Length815 aa

Sodium/hydrogen exchanger 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Sodium/hydrogen exchanger 1, mapped to UniProt P19634. Sequence length is 815 aa.

Mapped IDP19634
Review nameSodium/hydrogen exchanger 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
5
Phase II
Assay Mix

Activity Type Distribution

IC50450.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL465179 10.8 IC50 0.016 Preclinical
CHEMBL501701 9.72 IC50 0.19 Preclinical
CHEMBL392093 9.32 IC50 0.48 Preclinical
CHEMBL3900790 9.0 IC50 1.0 Preclinical
CHEMBL3980085 9.0 IC50 1.0 Preclinical
CHEMBL64889 8.7 IC50 2.0 Preclinical
CHEMBL3900457 8.7 IC50 2.0 Preclinical
CHEMBL419578 8.52 IC50 3.0 Preclinical
CHEMBL517986 8.43 IC50 3.7 Preclinical
CHEMBL384143 8.34 IC50 4.6 Preclinical
Distribution

pChEMBL Value Distribution

53
5.0
47
5.5
54
6.0
64
6.5
55
7.0
50
7.5
31
8.0
5
8.5
4
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

36
Total Assays
313
Tested Compounds
3
Assay Types
Binding — 28 assays, 313 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 17 230 6.4
single protein format 10 33 7.2
cell-free format 1 50 6.8
Functional — 7 assays, 43 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 42 6.7
assay format 2 1 7.5
ADME — 1 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 24 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine