Sterol O-acyltransferase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Sterol O-acyltransferase 1 shows approved-linked disease relevance led by diabetes mellitus. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P35610. Start with diabetes mellitus, then reuse UniProt P35610 as the stable protein anchor across project notes and exports.
Start with diabetes mellitus, then reuse UniProt P35610 as the stable protein anchor across project notes and exports.
Sterol O-acyltransferase 1 shows approved-linked disease relevance led by diabetes mellitus. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with diabetes mellitus because it currently carries approved-linked support. Linked drugs include BENFLUOREX. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySterol O-acyltransferase 1
Review this target as Sterol O-acyltransferase 1, mapped to UniProt P35610. Sequence length is 550 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sterol O-acyltransferase 1 as ChEMBL target CHEMBL2782, mapped to UniProt P35610. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Sterol O-acyltransferase 1 is the right protein anchor across sources, using UniProt P35610 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why diabetes mellitus is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Sterol O-acyltransferase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35610 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sterol O-acyltransferase 1 |
| UniProt Accession | P35610 |
| Component Type | Protein |
| Sequence Length | 550 aa |
Sterol O-acyltransferase 1
Review this target as Sterol O-acyltransferase 1, mapped to UniProt P35610. Sequence length is 550 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Sterol O-acyltransferase 1 shows approved-linked disease relevance led by diabetes mellitus. 3 more disease programs remain visible in the same review block.
Start review with diabetes mellitus because it currently carries approved-linked support. Linked drugs include BENFLUOREX. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4281138 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3936899 | 8.49 | IC50 | 3.2 | Preclinical |
| CHEMBL3899908 | 8.44 | IC50 | 3.6 | Preclinical |
| CHEMBL3894947 | 8.38 | IC50 | 4.2 | Preclinical |
| CHEMBL4247249 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL46423 | 8.05 | IC50 | 9.0 | Clinical |
| CHEMBL4282905 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL284596 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL3905226 | 7.99 | IC50 | 10.3 | Preclinical |
| CHEMBL449307 | 7.7 | IC50 | 20.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 53 | 161 | 5.7 |
| cell-based format | 50 | 249 | 5.7 |
| assay format | 14 | 14 | 6.2 |
| tissue-based format | 9 | 7 | 6.1 |
| microsome format | 1 | 1 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 6 | 1 | 6.0 |
| microsome format | 1 | 1 | 6.1 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 16 | 5.9 |