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Target Snapshot

CHEMBL2789 Target Snapshot

17-beta-hydroxysteroid dehydrogenase type 2 · SINGLE PROTEIN · Homo sapiens

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1,317Compounds
112Assays
0Approved Drugs
867.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P37059. Use UniProt P37059 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P37059 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 17-beta-hydroxysteroid dehydrogenase type 2 as ChEMBL target CHEMBL2789, mapped to UniProt P37059. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
17-beta-hydroxysteroid dehydrogenase type 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2789
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P37059
17-beta-hydroxysteroid dehydrogenase type 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 17-beta-hydroxysteroid dehydrogenase type 2 is the right protein anchor across sources, using UniProt P37059 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred Name17-beta-hydroxysteroid dehydrogenase type 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP37059
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label17-beta-hydroxysteroid dehydrogenase type 2
UniProt AccessionP37059
Component TypeProtein
Sequence Length387 aa

17-beta-hydroxysteroid dehydrogenase type 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as 17-beta-hydroxysteroid dehydrogenase type 2, mapped to UniProt P37059. Sequence length is 387 aa.

Mapped IDP37059
Review name17-beta-hydroxysteroid dehydrogenase type 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase III
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50864.0
KI3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4457145 9.7 IC50 0.2 Preclinical
CHEMBL4529443 9.7 IC50 0.2 Preclinical
CHEMBL4293115 9.49 IC50 0.32 Preclinical
CHEMBL4464314 9.4 IC50 0.4 Preclinical
CHEMBL4546082 9.4 IC50 0.4 Preclinical
CHEMBL4513439 9.22 IC50 0.6 Preclinical
CHEMBL4295076 9.2 IC50 0.63 Preclinical
CHEMBL4276934 9.07 IC50 0.85 Preclinical
CHEMBL4574253 9.05 IC50 0.9 Preclinical
CHEMBL4585585 9.0 IC50 1.0 Preclinical
Distribution

pChEMBL Value Distribution

76
5.0
103
5.5
163
6.0
128
6.5
68
7.0
39
7.5
51
8.0
31
8.5
8
9.0
2
9.5
pChEMBL
Assay Landscape

Assay Landscape

112
Total Assays
695
Tested Compounds
3
Assay Types
Binding — 108 assays, 695 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 52 358 6.6
cell-based format 35 43 5.8
single protein format 12 192 5.5
subcellular format 5 65 7.8
microsome format 4 37 6.3
ADME — 2 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 13 7.6
Functional — 2 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —
cell-based format 1 5 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine