Poly [ADP-ribose] polymerase 2 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt O88554. Use UniProt O88554 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O88554 as the stable identity anchor, then attach disease evidence before program review.
Poly [ADP-ribose] polymerase 2
Review this target as Poly [ADP-ribose] polymerase 2, mapped to UniProt O88554. Sequence length is 559 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Poly [ADP-ribose] polymerase 2 as ChEMBL target CHEMBL2794, mapped to UniProt O88554. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Poly [ADP-ribose] polymerase 2 is the right protein anchor across sources, using UniProt O88554 as the stable mapping.
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| Preferred Name | Poly [ADP-ribose] polymerase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O88554 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Poly [ADP-ribose] polymerase 2 |
| UniProt Accession | O88554 |
| Component Type | Protein |
| Sequence Length | 559 aa |
Poly [ADP-ribose] polymerase 2
Review this target as Poly [ADP-ribose] polymerase 2, mapped to UniProt O88554. Sequence length is 559 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4554200 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL3644587 | 9.0 | IC50 | 1.0 | Clinical |
| CHEMBL3219283 | 7.42 | IC50 | 38.0 | Preclinical |
| CHEMBL1767067 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL2414044 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL2414046 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL2414042 | 6.77 | IC50 | 170.0 | Preclinical |
| CHEMBL2414048 | 6.58 | IC50 | 260.0 | Preclinical |
| CHEMBL3219282 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL2414043 | 6.32 | IC50 | 480.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 36 | 6.1 |