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Target Snapshot

CHEMBL2799 Target Snapshot

Sodium-dependent dopamine transporter · SINGLE PROTEIN · Mus musculus

118Compounds
12Assays
5Approved Drugs
56.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q61327. Use UniProt Q61327 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q61327 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium-dependent dopamine transporter as ChEMBL target CHEMBL2799, mapped to UniProt Q61327. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium-dependent dopamine transporter
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2799
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q61327
Sodium-dependent dopamine transporter
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium-dependent dopamine transporter is the right protein anchor across sources, using UniProt Q61327 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium-dependent dopamine transporter
UniProt AccessionQ61327
Component TypeProtein
Sequence Length619 aa

Sodium-dependent dopamine transporter

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Sodium-dependent dopamine transporter, mapped to UniProt Q61327. Sequence length is 619 aa.

Mapped IDQ61327
Review nameSodium-dependent dopamine transporter
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

5
Approved
1
Phase III
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC507.0
KI44.0
EC505.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL285506 9.0 Ki 0.99 Preclinical
CHEMBL330666 8.59 Ki 2.6 Preclinical
CHEMBL96362 8.49 Ki 3.2 Preclinical
CHEMBL1173532 8.0 Ki 10.0 Preclinical
CHEMBL35184 7.95 Ki 11.3 Preclinical
CHEMBL281594 7.92 Ki 12.0 Clinical
CHEMBL781 7.89 IC50 13.0 Approved
CHEMBL327790 7.63 Ki 23.5 Preclinical
CHEMBL94535 7.56 Ki 27.4 Preclinical
CHEMBL95153 7.36 Ki 43.7 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
16
5.5
7
6.0
9
6.5
7
7.0
5
7.5
2
8.0
1
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

COCAINE
CHEMBL370805
Approved 2017
PAROXETINE
CHEMBL490
Approved 1992
MAZINDOL
CHEMBL781
Approved 1973
Assay Landscape

Assay Landscape

12
Total Assays
44
Tested Compounds
2
Assay Types
Binding — 7 assays, 44 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 7 6.0
cell membrane format 2 12 6.1
single protein format 1 24 6.9
tissue-based format 1 1 8.0
Functional — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 3 0
assay format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine