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Target Snapshot

CHEMBL2804 Target Snapshot

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 · SINGLE PROTEIN · Rattus norvegicus

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46Compounds
58Assays
0Approved Drugs
140.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P29994. Use UniProt P29994 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P29994 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 as ChEMBL target CHEMBL2804, mapped to UniProt P29994. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL2804
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P29994
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 is the right protein anchor across sources, using UniProt P29994 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameInositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP29994
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelInositol 1,4,5-trisphosphate-gated calcium channel ITPR1
UniProt AccessionP29994
Component TypeProtein
Sequence Length2750 aa

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1, mapped to UniProt P29994. Sequence length is 2750 aa.

Mapped IDP29994
Review nameInositol 1,4,5-trisphosphate-gated calcium channel ITPR1
OrganismRattus norvegicus
Assay Mix

Activity Type Distribution

EC5073.0
KD67.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1212943 9.85 Kd 0.14 Preclinical
CHEMBL1213158 9.74 Kd 0.18 Preclinical
CHEMBL1213159 9.74 Kd 0.18 Preclinical
CHEMBL1213160 9.7 Kd 0.2 Preclinical
CHEMBL1213163 9.7 Kd 0.2 Preclinical
CHEMBL279107 9.68 Kd 0.21 Preclinical
CHEMBL1213201 9.66 Kd 0.22 Preclinical
CHEMBL1213161 9.48 Kd 0.33 Preclinical
CHEMBL1213202 9.28 Kd 0.52 Preclinical
CHEMBL204385 8.9 Kd 1.26 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
6
5.5
3
6.0
16
6.5
16
7.0
24
7.5
16
8.0
16
8.5
17
9.0
9
9.5
pChEMBL
Assay Landscape

Assay Landscape

58
Total Assays
27
Tested Compounds
2
Assay Types
Binding — 42 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 38 17 8.1
cell membrane format 2 8 7.1
single protein format 2 0 —
Functional — 16 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 27 7.5
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine