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Target Snapshot

CHEMBL281 Target Snapshot

Carbonic anhydrase 4 · SINGLE PROTEIN · Bos taurus

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1,417Compounds
40Assays
18Approved Drugs
1,556.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q95323. Use UniProt Q95323 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q95323 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 4 as ChEMBL target CHEMBL281, mapped to UniProt Q95323. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 4
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL281
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q95323
Carbonic anhydrase 4
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase 4 is the right protein anchor across sources, using UniProt Q95323 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCarbonic anhydrase 4
Target TypeSINGLE PROTEIN
OrganismBos taurus
UniProtQ95323
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase 4
UniProt AccessionQ95323
Component TypeProtein
Sequence Length312 aa

Carbonic anhydrase 4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Carbonic anhydrase 4, mapped to UniProt Q95323. Sequence length is 312 aa.

Mapped IDQ95323
Review nameCarbonic anhydrase 4
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

18
Approved
1
Phase III
3
Phase II
Assay Mix

Activity Type Distribution

IC5018.0
KI1,538.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL158693 9.22 Ki 0.6 Preclinical
CHEMBL13630 9.1 Ki 0.8 Preclinical
CHEMBL331083 9.1 Ki 0.8 Preclinical
CHEMBL275565 8.89 Ki 1.3 Preclinical
CHEMBL69229 8.77 Ki 1.7 Preclinical
CHEMBL302706 8.72 Ki 1.9 Preclinical
CHEMBL304757 8.72 Ki 1.9 Preclinical
CHEMBL305488 8.7 Ki 2.0 Preclinical
CHEMBL71611 8.7 Ki 2.0 Preclinical
CHEMBL77402 8.7 Ki 2.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
76
5.5
195
6.0
303
6.5
382
7.0
260
7.5
172
8.0
21
8.5
4
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VALDECOXIB
CHEMBL865
Approved 2001
Properties Compare Identifier
BRINZOLAMIDE
CHEMBL220491
Approved 1998
Properties Compare Identifier
CELECOXIB
CHEMBL118
Approved 1998
Properties Compare Identifier
TOPIRAMATE
CHEMBL220492
Approved 1996
Properties Compare Identifier
DORZOLAMIDE
CHEMBL218490
Approved 1994
Properties Compare Identifier
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
Properties Compare Identifier
METHAZOLAMIDE
CHEMBL19
Approved 1959
Properties Compare Identifier
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
Properties Compare Identifier
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

40
Total Assays
1,300
Tested Compounds
2
Assay Types
Binding — 38 assays, 1,300 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 20 567 7.2
assay format 16 733 7.0
microsome format 2 0 —
Functional — 2 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 8 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine