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Evidence Snapshot

Coagulation factor XI

CHEMBL2820 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:36Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2820
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Coagulation factor XI as ChEMBL target CHEMBL2820, mapped to UniProt P03951. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Coagulation factor XI
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2820
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P03951
Coagulation factor XI
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Coagulation factor XI matters

As of 2026-09-13

Coagulation factor XI is reviewed as Coagulation factor XI (UniProt P03951); Coagulation factor XI shows approved-linked disease relevance led by hereditary angioedema. 5 more disease programs remain visible in the same review block.; 1 linked drug keep this evidence frame grounded.; the current evidence base includes 1 approved drug, 3720 compounds, and 266 assays, with lead potency reaching pChEMBL 10.7.

Disease context
hereditary angioedema

Coagulation factor XI shows approved-linked disease relevance led by hereditary angioedema. 5 more disease programs remain visible in the same review block. 1 linked drug keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include HUMAN C1-ESTERASE INHIBITOR.

Start review with hereditary angioedema because it currently carries approved-linked support. Linked drugs include HUMAN C1-ESTERASE INHIBITOR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Approved-linked 1 linked drug
Activity base
Portfolio and assay base

ChEMBL currently tracks 1 approved drug, 3720 compounds, and 266 assays for this target. The dominant activity type is IC50. CHEMBL4096251 is the current potency anchor at pChEMBL 10.7.

Use CHEMBL4096251 as the tractability anchor when discussing potency (pChEMBL 10.7).

Activity source · ChEMBL 36 via Core Engine
1 approved pChEMBL 10.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Coagulation factor XI matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P03951, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why hereditary angioedema is currently treated as approved-linked support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

3720
Total Compounds
266
Total Assays
1
Approved Drugs
IC50: 3244.0, KI: 2099.0, EC50: 12.0, KD: 9.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4096251
 10.7 Ki —
No preferred name
CHEMBL4060950
 10.5 Ki —
No preferred name
CHEMBL4107149
 10.5 Ki —
No preferred name
CHEMBL3580759
 10.4 Ki —
No preferred name
CHEMBL4110926
 10.4 Ki —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:36Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2820