Protein phosphatase 1B · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt O75688. Use UniProt O75688 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O75688 as the stable identity anchor, then attach disease evidence before program review.
Protein phosphatase 1B
Review this target as Protein phosphatase 1B, mapped to UniProt O75688. Sequence length is 479 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein phosphatase 1B as ChEMBL target CHEMBL2845, mapped to UniProt O75688. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Protein phosphatase 1B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O75688 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein phosphatase 1B |
| UniProt Accession | O75688 |
| Component Type | Protein |
| Sequence Length | 479 aa |
Protein phosphatase 1B
Review this target as Protein phosphatase 1B, mapped to UniProt O75688. Sequence length is 479 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL421377 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL280487 | 6.9 | IC50 | 126.0 | Preclinical |
| CHEMBL48449 | 6.37 | IC50 | 430.0 | Approved |
| CHEMBL5188453 | 6.28 | Ki | 520.0 | Preclinical |
| CHEMBL8327 | 6.24 | IC50 | 570.0 | Preclinical |
| CHEMBL318253 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL100883 | 5.55 | IC50 | 2820.0 | Preclinical |
| CHEMBL48076 | 5.53 | IC50 | 2960.0 | Preclinical |
| CHEMBL100935 | 5.49 | IC50 | 3220.0 | Preclinical |
| CHEMBL47665 | 5.33 | IC50 | 4710.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 21 | 5.8 |
| tissue-based format | 2 | 12 | 5.0 |
| assay format | 1 | 1 | 6.3 |
| cell-based format | 1 | 0 | — |