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Evidence Snapshot

Glycogen synthase kinase-3 alpha

CHEMBL2850 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:14:10Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2850
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glycogen synthase kinase-3 alpha as ChEMBL target CHEMBL2850, mapped to UniProt P49840. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glycogen synthase kinase-3 alpha
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2850
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P49840
Glycogen synthase kinase-3 alpha
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Glycogen synthase kinase-3 alpha matters

As of 2026-09-14

Glycogen synthase kinase-3 alpha is reviewed as Glycogen synthase kinase-3 alpha (UniProt P49840); Glycogen synthase kinase-3 alpha shows clinical signal disease relevance led by leukemia. 2 more disease programs remain visible in the same review block.; 1 linked drug keep this evidence frame grounded.; the current evidence base includes 5 approved drugs, 3702 compounds, and 531 assays, with lead potency reaching pChEMBL 10.2.

Disease context
leukemia

Glycogen synthase kinase-3 alpha shows clinical signal disease relevance led by leukemia. 2 more disease programs remain visible in the same review block. 1 linked drug keep the rationale reviewable. 2 additional disease programs remain visible in the same card. Linked drugs include LY-2090314.

Start review with leukemia because it currently carries clinical signal support. Linked drugs include LY-2090314. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Clinical signal 1 linked drug
Activity base
Portfolio and assay base

ChEMBL currently tracks 5 approved drugs, 3702 compounds, and 531 assays for this target. The dominant activity type is IC50. CHEMBL5409061 is the current potency anchor at pChEMBL 10.2.

Use CHEMBL5409061 as the tractability anchor when discussing potency (pChEMBL 10.2).

Activity source · ChEMBL 36 via Core Engine
5 approved pChEMBL 10.2
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Glycogen synthase kinase-3 alpha matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P49840, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why leukemia is currently treated as clinical signal support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

3702
Total Compounds
531
Total Assays
5
Approved Drugs
IC50: 2011.0, KI: 988.0, KD: 386.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5409061
 10.2 IC50 —
No preferred name
CHEMBL5270781
 10.1 IC50 —
No preferred name
CHEMBL5286391
 10.1 IC50 —
No preferred name
CHEMBL5266553
 10.0 IC50 —
No preferred name
CHEMBL5428013
 9.8 IC50 —

Approved Drugs

Structure Compound First Approval
ABEMACICLIB
CHEMBL3301610
 2017
NINTEDANIB
CHEMBL502835
 2014
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:14:10Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2850