Metabotropic glutamate receptor 2 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P31421. Use UniProt P31421 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31421 as the stable identity anchor, then attach disease evidence before program review.
Metabotropic glutamate receptor 2
Review this target as Metabotropic glutamate receptor 2, mapped to UniProt P31421. Sequence length is 872 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Metabotropic glutamate receptor 2 as ChEMBL target CHEMBL2851, mapped to UniProt P31421. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Metabotropic glutamate receptor 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P31421 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Metabotropic glutamate receptor 2 |
| UniProt Accession | P31421 |
| Component Type | Protein |
| Sequence Length | 872 aa |
Metabotropic glutamate receptor 2
Review this target as Metabotropic glutamate receptor 2, mapped to UniProt P31421. Sequence length is 872 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL121053 | 9.24 | EC50 | 0.57 | Preclinical |
| CHEMBL5571283 | 9.24 | EC50 | 0.5754 | Preclinical |
| CHEMBL275079 | 9.22 | EC50 | 0.6 | Preclinical |
| CHEMBL365305 | 8.97 | Ki | 1.06 | Preclinical |
| CHEMBL182972 | 8.84 | Ki | 1.45 | Preclinical |
| CHEMBL365680 | 8.83 | Ki | 1.48 | Preclinical |
| CHEMBL184983 | 8.79 | Ki | 1.61 | Preclinical |
| CHEMBL263312 | 8.75 | Ki | 1.79 | Preclinical |
| CHEMBL1631876 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL1629855 | 8.7 | IC50 | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 55 | 182 | 6.6 |
| assay format | 23 | 63 | 6.5 |
| single protein format | 4 | 1 | 7.3 |
| cell membrane format | 3 | 1 | 6.8 |
| tissue-based format | 1 | 1 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 43 | 273 | 7.0 |
| single protein format | 17 | 93 | 7.4 |
| assay format | 4 | 36 | 6.5 |