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Target Snapshot

CHEMBL2854 Target Snapshot

Gastrin/cholecystokinin type B receptor · SINGLE PROTEIN · Mus musculus

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667Compounds
89Assays
4Approved Drugs
690.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P56481. Use UniProt P56481 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P56481 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Gastrin/cholecystokinin type B receptor as ChEMBL target CHEMBL2854, mapped to UniProt P56481. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Gastrin/cholecystokinin type B receptor
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL2854
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P56481
Gastrin/cholecystokinin type B receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Gastrin/cholecystokinin type B receptor is the right protein anchor across sources, using UniProt P56481 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameGastrin/cholecystokinin type B receptor
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtP56481
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGastrin/cholecystokinin type B receptor
UniProt AccessionP56481
Component TypeProtein
Sequence Length453 aa

Gastrin/cholecystokinin type B receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Gastrin/cholecystokinin type B receptor, mapped to UniProt P56481. Sequence length is 453 aa.

Mapped IDP56481
Review nameGastrin/cholecystokinin type B receptor
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50484.0
KI200.0
EC506.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2062146 10.08 IC50 0.083 Preclinical
CHEMBL505969 9.85 EC50 0.14 Preclinical
CHEMBL138534 9.83 Ki 0.1479 Preclinical
CHEMBL138534 9.82 IC50 0.15 Preclinical
CHEMBL356898 9.82 IC50 0.15 Preclinical
CHEMBL354049 9.7 Ki 0.2 Preclinical
CHEMBL359292 9.68 IC50 0.21 Preclinical
CHEMBL1121 9.52 IC50 0.3 Approved
CHEMBL2115544 9.52 IC50 0.3 Preclinical
CHEMBL269098 9.52 IC50 0.3 Preclinical
Distribution

pChEMBL Value Distribution

42
5.0
61
5.5
91
6.0
104
6.5
83
7.0
93
7.5
80
8.0
48
8.5
20
9.0
17
9.5
pChEMBL
Approved Drugs

Approved Drugs

SINCALIDE
CHEMBL1121
Approved 1976
Properties Compare Identifier
PENTAGASTRIN
CHEMBL1328
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

89
Total Assays
584
Tested Compounds
2
Assay Types
Binding — 73 assays, 584 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 50 348 7.2
assay format 9 117 6.9
cell membrane format 8 76 7.0
single protein format 5 43 6.5
cell-based format 1 0 —
Functional — 16 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 9 0 —
assay format 7 6 9.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine