Human rhinovirus A protease · SINGLE PROTEIN · Human rhinovirus sp.
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As of 2026-09-13Protein identity stays anchored to UniProt Q4U254. Use UniProt Q4U254 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q4U254 as the stable identity anchor, then attach disease evidence before program review.
Genome polyprotein
Review this target as Human rhinovirus A protease, mapped to UniProt Q4U254. ChEMBL maps the protein component as Genome polyprotein. Sequence length is 401 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Human rhinovirus A protease as ChEMBL target CHEMBL2857, mapped to UniProt Q4U254. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Human rhinovirus A protease is the right protein anchor across sources, using UniProt Q4U254 as the stable mapping.
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| Preferred Name | Human rhinovirus A protease |
| Target Type | SINGLE PROTEIN |
| Organism | Human rhinovirus sp. |
| UniProt | Q4U254 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Genome polyprotein |
| UniProt Accession | Q4U254 |
| Component Type | Protein |
| Sequence Length | 401 aa |
Genome polyprotein
Review this target as Human rhinovirus A protease, mapped to UniProt Q4U254. ChEMBL maps the protein component as Genome polyprotein. Sequence length is 401 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL13134 | 9.89 | Ki | 0.13 | Clinical |
| CHEMBL17612 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL114 | 9.3 | IC50 | 0.5 | Approved |
| CHEMBL279448 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL291277 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL304086 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL117484 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL289920 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL267571 | 8.64 | IC50 | 2.3 | Preclinical |
| CHEMBL145830 | 8.52 | Ki | 3.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 174 | 360 | 6.1 |
| assay format | 13 | 56 | 6.1 |
| cell-based format | 11 | 6 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 63 | 48 | 6.8 |
| cell-based format | 5 | 18 | 5.3 |
| organism-based format | 1 | 0 | — |