Thymidine kinase, cytosolic · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P04183. Use UniProt P04183 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04183 as the stable identity anchor, then attach disease evidence before program review.
Thymidine kinase, cytosolic
Review this target as Thymidine kinase, cytosolic, mapped to UniProt P04183. Sequence length is 234 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thymidine kinase, cytosolic as ChEMBL target CHEMBL2883, mapped to UniProt P04183. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Thymidine kinase, cytosolic |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P04183 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thymidine kinase, cytosolic |
| UniProt Accession | P04183 |
| Component Type | Protein |
| Sequence Length | 234 aa |
Thymidine kinase, cytosolic
Review this target as Thymidine kinase, cytosolic, mapped to UniProt P04183. Sequence length is 234 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL132598 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5653589 | 7.81 | Kd | 15.33 | Preclinical |
| CHEMBL52609 | 7.8 | IC50 | 16.0 | Clinical |
| CHEMBL406254 | 7.3 | Ki | 50.0 | Preclinical |
| CHEMBL1269499 | 7.05 | Ki | 90.0 | Preclinical |
| CHEMBL788 | 7.05 | Ki | 90.0 | Approved |
| CHEMBL31634 | 7.0 | Ki | 100.0 | Clinical |
| CHEMBL271475 | 6.85 | Ki | 140.0 | Clinical |
| CHEMBL101135 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL475717 | 6.75 | Ki | 180.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 109 | 92 | 5.1 |
| cell-based format | 14 | 5 | 6.8 |
| assay format | 3 | 1 | 5.4 |
| mitochondrion format | 1 | 1 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 16 | 10 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |