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Target Snapshot

CHEMBL2888 Target Snapshot

Metabotropic glutamate receptor 3 · SINGLE PROTEIN · Homo sapiens

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344Compounds
176Assays
0Approved Drugs
496.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Metabotropic glutamate receptor 3 shows late clinical disease relevance led by schizophrenia. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q14832. Start with schizophrenia, then reuse UniProt Q14832 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with schizophrenia, then reuse UniProt Q14832 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
schizophrenia

Metabotropic glutamate receptor 3 shows late clinical disease relevance led by schizophrenia. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with schizophrenia because it currently carries late clinical support. Linked drugs include POMAGLUMETAD METHIONIL ANHYDROUS. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Late clinical Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Metabotropic glutamate receptor 3 as ChEMBL target CHEMBL2888, mapped to UniProt Q14832. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Metabotropic glutamate receptor 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2888
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q14832
Metabotropic glutamate receptor 3
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Metabotropic glutamate receptor 3 is the right protein anchor across sources, using UniProt Q14832 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why schizophrenia is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameMetabotropic glutamate receptor 3
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ14832
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMetabotropic glutamate receptor 3
UniProt AccessionQ14832
Component TypeProtein
Sequence Length879 aa

Metabotropic glutamate receptor 3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Metabotropic glutamate receptor 3, mapped to UniProt Q14832. Sequence length is 879 aa.

Mapped IDQ14832
Review nameMetabotropic glutamate receptor 3
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Late clinical Open Targets-ready proxy

Metabotropic glutamate receptor 3 shows late clinical disease relevance led by schizophrenia. 5 more disease programs remain visible in the same review block.

Late clinical Phase III
schizophrenia
1 linked drug · 1 direct · 1 efficacy
Linked drugPOMAGLUMETAD METHIONIL ANHYDROUS
Clinical signal Phase II
depressive disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugDECOGLURANT
Clinical signal Phase II
major depressive disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugDECOGLURANT
Clinical signal Phase I
methamphetamine dependence
1 linked drug · 1 direct · 1 efficacy
Linked drugPOMAGLUMETAD METHIONIL ANHYDROUS
Clinical signal Phase I
post-traumatic stress disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugPOMAGLUMETAD METHIONIL ANHYDROUS
Clinical signal Phase I
psychosis
1 linked drug · 1 direct · 1 efficacy
Linked drugPOMAGLUMETAD METHIONIL ANHYDROUS
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with schizophrenia because it currently carries late clinical support. Linked drugs include POMAGLUMETAD METHIONIL ANHYDROUS. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseschizophrenia
Strongest levelLate clinical
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

2
Phase III
3
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50209.0
KI102.0
EC50185.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2381640 9.96 EC50 0.11 Preclinical
CHEMBL4068189 9.77 EC50 0.17 Preclinical
CHEMBL218710 9.77 Ki 0.17 Preclinical
CHEMBL2381652 9.62 EC50 0.24 Preclinical
CHEMBL4081453 9.33 EC50 0.47 Preclinical
CHEMBL4071962 9.33 Ki 0.47 Preclinical
CHEMBL4091735 9.15 EC50 0.71 Preclinical
CHEMBL4071962 9.09 EC50 0.82 Preclinical
CHEMBL4081453 9.03 Ki 0.927 Preclinical
CHEMBL432038 8.89 Ki 1.3 Preclinical
Distribution

pChEMBL Value Distribution

36
5.0
32
5.5
33
6.0
58
6.5
59
7.0
37
7.5
36
8.0
15
8.5
5
9.0
4
9.5
pChEMBL
Assay Landscape

Assay Landscape

176
Total Assays
148
Tested Compounds
3
Assay Types
Functional — 102 assays, 148 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 76 113 6.7
assay format 19 31 6.0
cell membrane format 4 3 8.1
single protein format 3 1 5.4
Binding — 72 assays, 107 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 47 10 6.9
cell-based format 22 61 7.2
assay format 2 19 7.2
cell membrane format 1 17 7.6
ADME — 2 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 1 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine