Folylpolyglutamate synthase, mitochondrial · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P48760. Use UniProt P48760 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P48760 as the stable identity anchor, then attach disease evidence before program review.
Folylpolyglutamate synthase, mitochondrial
Review this target as Folylpolyglutamate synthase, mitochondrial, mapped to UniProt P48760. Sequence length is 587 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Folylpolyglutamate synthase, mitochondrial as ChEMBL target CHEMBL2890, mapped to UniProt P48760. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Folylpolyglutamate synthase, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P48760 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Folylpolyglutamate synthase, mitochondrial |
| UniProt Accession | P48760 |
| Component Type | Protein |
| Sequence Length | 587 aa |
Folylpolyglutamate synthase, mitochondrial
Review this target as Folylpolyglutamate synthase, mitochondrial, mapped to UniProt P48760. Sequence length is 587 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL289923 | 7.52 | Ki | 30.0 | Preclinical |
| CHEMBL23977 | 7.17 | Ki | 67.0 | Preclinical |
| CHEMBL280864 | 6.82 | Ki | 150.0 | Preclinical |
| CHEMBL281656 | 6.52 | Ki | 300.0 | Preclinical |
| CHEMBL89641 | 5.7 | Ki | 2000.0 | Preclinical |
| CHEMBL316019 | 5.64 | Ki | 2300.0 | Preclinical |
| CHEMBL38902 | 5.5 | Ki | 3200.0 | Preclinical |
| CHEMBL28049 | 5.4 | Ki | 4000.0 | Preclinical |
| CHEMBL35921 | 5.24 | Ki | 5700.0 | Preclinical |
| CHEMBL281024 | 5.08 | Ki | 8400.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 25 | 14 | 5.4 |
| single protein format | 14 | 6 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 0 | — |