Dual specificity mitogen-activated protein kinase kinase 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P45985. Use UniProt P45985 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P45985 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity mitogen-activated protein kinase kinase 4
Review this target as Dual specificity mitogen-activated protein kinase kinase 4, mapped to UniProt P45985. Sequence length is 399 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity mitogen-activated protein kinase kinase 4 as ChEMBL target CHEMBL2897, mapped to UniProt P45985. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dual specificity mitogen-activated protein kinase kinase 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P45985 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity mitogen-activated protein kinase kinase 4 |
| UniProt Accession | P45985 |
| Component Type | Protein |
| Sequence Length | 399 aa |
Dual specificity mitogen-activated protein kinase kinase 4
Review this target as Dual specificity mitogen-activated protein kinase kinase 4, mapped to UniProt P45985. Sequence length is 399 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4865410 | 8.82 | Kd | 1.5 | Preclinical |
| CHEMBL4798975 | 8.77 | Kd | 1.7 | Preclinical |
| CHEMBL603469 | 8.42 | Kd | 3.8 | Clinical |
| CHEMBL4790247 | 7.54 | IC50 | 29.0 | Preclinical |
| CHEMBL4758063 | 7.39 | IC50 | 41.0 | Preclinical |
| CHEMBL6062934 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL4879048 | 7.21 | IC50 | 61.0 | Preclinical |
| CHEMBL5923880 | 7.2 | IC50 | 63.0 | Preclinical |
| CHEMBL388978 | 7.16 | Kd | 70.0 | Preclinical |
| CHEMBL4866649 | 7.08 | IC50 | 83.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 156 | 108 | 6.2 |
| cell-based format | 37 | 39 | 5.9 |
| assay format | 32 | 2 | 8.8 |
| subcellular format | 25 | 3 | 6.3 |