Adenylate cyclase type 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q08828. Use UniProt Q08828 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q08828 as the stable identity anchor, then attach disease evidence before program review.
Adenylate cyclase type 1
Review this target as Adenylate cyclase type 1, mapped to UniProt Q08828. Sequence length is 1119 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adenylate cyclase type 1 as ChEMBL target CHEMBL2899, mapped to UniProt Q08828. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Adenylate cyclase type 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q08828 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenylate cyclase type 1 |
| UniProt Accession | Q08828 |
| Component Type | Protein |
| Sequence Length | 1119 aa |
Adenylate cyclase type 1
Review this target as Adenylate cyclase type 1, mapped to UniProt Q08828. Sequence length is 1119 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL328689 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL328561 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL92229 | 7.5 | IC50 | 32.0 | Preclinical |
| CHEMBL329247 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL93009 | 7.41 | IC50 | 39.0 | Preclinical |
| CHEMBL52606 | 7.39 | IC50 | 41.0 | Clinical |
| CHEMBL317990 | 7.37 | IC50 | 43.0 | Preclinical |
| CHEMBL432817 | 7.36 | IC50 | 44.0 | Preclinical |
| CHEMBL93242 | 7.19 | IC50 | 64.0 | Preclinical |
| CHEMBL93259 | 7.19 | IC50 | 65.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 101 | 5.4 |
| assay format | 3 | 45 | 6.9 |
| cell membrane format | 2 | 0 | — |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 8 | 44 | 5.7 |
| cell membrane format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |