cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q13370. Use UniProt Q13370 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q13370 as the stable identity anchor, then attach disease evidence before program review.
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Review this target as cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B, mapped to UniProt Q13370. Sequence length is 1112 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B as ChEMBL target CHEMBL290, mapped to UniProt Q13370. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q13370 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B |
| UniProt Accession | Q13370 |
| Component Type | Protein |
| Sequence Length | 1112 aa |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Review this target as cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B, mapped to UniProt Q13370. Sequence length is 1112 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL338860 | 10.31 | IC50 | 0.049 | Preclinical |
| CHEMBL339210 | 10.17 | IC50 | 0.068 | Preclinical |
| CHEMBL131355 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL129668 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL131111 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL128456 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL338179 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL128391 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL128621 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL129283 | 9.48 | IC50 | 0.33 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 56 | 162 | 5.8 |
| cell-based format | 24 | 42 | 6.6 |
| assay format | 2 | 319 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 1 | 7.3 |