Dihydrofolate reductase · SINGLE PROTEIN · Lactobacillus casei
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P00381. Use UniProt P00381 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00381 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P00381. Sequence length is 163 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL2902, mapped to UniProt P00381. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dihydrofolate reductase is the right protein anchor across sources, using UniProt P00381 as the stable mapping.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Lactobacillus casei |
| UniProt | P00381 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | P00381 |
| Component Type | Protein |
| Sequence Length | 163 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P00381. Sequence length is 163 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL31924 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL286400 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL31713 | 9.22 | Ki | 0.6 | Preclinical |
| CHEMBL31887 | 9.05 | Ki | 0.9 | Preclinical |
| CHEMBL34259 | 8.89 | IC50 | 1.3 | Approved |
| CHEMBL7492 | 8.82 | IC50 | 1.5 | Clinical |
| CHEMBL44684 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL33815 | 8.66 | IC50 | 2.2 | Preclinical |
| CHEMBL41056 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL18925 | 8.46 | IC50 | 3.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 90 | 285 | 6.2 |
| assay format | 6 | 15 | 6.7 |
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 13 | 5 | 7.8 |