Polyunsaturated fatty acid lipoxygenase ALOX15 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P16050. Use UniProt P16050 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P16050 as the stable identity anchor, then attach disease evidence before program review.
Polyunsaturated fatty acid lipoxygenase ALOX15
Review this target as Polyunsaturated fatty acid lipoxygenase ALOX15, mapped to UniProt P16050. Sequence length is 662 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Polyunsaturated fatty acid lipoxygenase ALOX15 as ChEMBL target CHEMBL2903, mapped to UniProt P16050. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Polyunsaturated fatty acid lipoxygenase ALOX15 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P16050 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Polyunsaturated fatty acid lipoxygenase ALOX15 |
| UniProt Accession | P16050 |
| Component Type | Protein |
| Sequence Length | 662 aa |
Polyunsaturated fatty acid lipoxygenase ALOX15
Review this target as Polyunsaturated fatty acid lipoxygenase ALOX15, mapped to UniProt P16050. Sequence length is 662 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3622746 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL3604156 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3604185 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL3781002 | 8.47 | IC50 | 3.4 | Preclinical |
| CHEMBL3604184 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL3633564 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL1271117 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL4301351 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL3290441 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL3604180 | 7.89 | IC50 | 13.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 130 | 275 | 5.8 |
| cell-based format | 42 | 70 | 6.6 |
| assay format | 34 | 69 | 5.6 |
| tissue-based format | 16 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |