Dihydropteridine reductase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P11348. Use UniProt P11348 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11348 as the stable identity anchor, then attach disease evidence before program review.
Dihydropteridine reductase
Review this target as Dihydropteridine reductase, mapped to UniProt P11348. Sequence length is 241 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydropteridine reductase as ChEMBL target CHEMBL2910, mapped to UniProt P11348. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dihydropteridine reductase is the right protein anchor across sources, using UniProt P11348 as the stable mapping.
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| Preferred Name | Dihydropteridine reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P11348 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydropteridine reductase |
| UniProt Accession | P11348 |
| Component Type | Protein |
| Sequence Length | 241 aa |
Dihydropteridine reductase
Review this target as Dihydropteridine reductase, mapped to UniProt P11348. Sequence length is 241 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL324880 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL110377 | 6.55 | IC50 | 280.0 | Preclinical |
| CHEMBL323998 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL109090 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL105897 | 5.72 | IC50 | 1900.0 | Preclinical |
| CHEMBL109090 | 5.72 | Ki | 1900.0 | Preclinical |
| CHEMBL108967 | 5.58 | IC50 | 2600.0 | Preclinical |
| CHEMBL108679 | 5.51 | IC50 | 3100.0 | Preclinical |
| CHEMBL323998 | 5.48 | Ki | 3300.0 | Preclinical |
| CHEMBL108787 | 5.47 | IC50 | 3400.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| subcellular format | 2 | 26 | 5.3 |
| single protein format | 1 | 3 | 5.1 |