Purine nucleoside phosphorylase · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P55859. Use UniProt P55859 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P55859 as the stable identity anchor, then attach disease evidence before program review.
Purine nucleoside phosphorylase
Review this target as Purine nucleoside phosphorylase, mapped to UniProt P55859. Sequence length is 289 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Purine nucleoside phosphorylase as ChEMBL target CHEMBL2935, mapped to UniProt P55859. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Purine nucleoside phosphorylase is the right protein anchor across sources, using UniProt P55859 as the stable mapping.
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| Preferred Name | Purine nucleoside phosphorylase |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P55859 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Purine nucleoside phosphorylase |
| UniProt Accession | P55859 |
| Component Type | Protein |
| Sequence Length | 289 aa |
Purine nucleoside phosphorylase
Review this target as Purine nucleoside phosphorylase, mapped to UniProt P55859. Sequence length is 289 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL218291 | 10.64 | Kd | 0.023 | Approved |
| CHEMBL218291 | 10.64 | Ki | 0.023 | Approved |
| CHEMBL473922 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL2311112 | 10.38 | Ki | 0.042 | Preclinical |
| CHEMBL41949 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL159640 | 10.17 | IC50 | 0.067 | Preclinical |
| CHEMBL236709 | 10.0 | Kd | 0.1 | Preclinical |
| CHEMBL269864 | 10.0 | Ki | 0.1 | Clinical |
| CHEMBL162255 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL352454 | 9.8 | IC50 | 0.16 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 17 | 16 | 8.8 |
| tissue-based format | 17 | 65 | 7.2 |
| assay format | 10 | 9 | 7.7 |