Cathepsin S · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Cathepsin S shows clinical signal disease relevance led by Sjogren syndrome. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P25774. Start with Sjogren syndrome, then reuse UniProt P25774 as the stable protein anchor across project notes and exports.
Start with Sjogren syndrome, then reuse UniProt P25774 as the stable protein anchor across project notes and exports.
Cathepsin S shows clinical signal disease relevance led by Sjogren syndrome. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Sjogren syndrome because it currently carries clinical signal support. Linked drugs include PETESICATIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCathepsin S
Review this target as Cathepsin S, mapped to UniProt P25774. Sequence length is 331 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cathepsin S as ChEMBL target CHEMBL2954, mapped to UniProt P25774. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Cathepsin S is the right protein anchor across sources, using UniProt P25774 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Sjogren syndrome is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Cathepsin S |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P25774 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cathepsin S |
| UniProt Accession | P25774 |
| Component Type | Protein |
| Sequence Length | 331 aa |
Cathepsin S
Review this target as Cathepsin S, mapped to UniProt P25774. Sequence length is 331 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Cathepsin S shows clinical signal disease relevance led by Sjogren syndrome. 2 more disease programs remain visible in the same review block.
Start review with Sjogren syndrome because it currently carries clinical signal support. Linked drugs include PETESICATIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5573840 | 10.8 | Ki | 0.016 | Preclinical |
| CHEMBL3651506 | 10.54 | IC50 | 0.029 | Preclinical |
| CHEMBL3651502 | 10.28 | IC50 | 0.052 | Preclinical |
| CHEMBL3651503 | 10.25 | IC50 | 0.056 | Preclinical |
| CHEMBL3651507 | 10.25 | IC50 | 0.056 | Preclinical |
| CHEMBL3651508 | 10.21 | IC50 | 0.061 | Preclinical |
| CHEMBL4777335 | 10.05 | Ki | 0.09 | Preclinical |
| CHEMBL155560 | 10.0 | Kd | 0.1 | Preclinical |
| CHEMBL2207565 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4297638 | 10.0 | IC50 | 0.1 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 236 | 2,291 | 7.2 |
| cell-based format | 36 | 199 | 6.6 |
| assay format | 20 | 242 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 9 | 9 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 4 | 7.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 7.5 |