Gamma-aminobutyric acid receptor subunit gamma-1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P23574. Use UniProt P23574 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P23574 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit gamma-1
Review this target as Gamma-aminobutyric acid receptor subunit gamma-1, mapped to UniProt P23574. Sequence length is 465 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Gamma-aminobutyric acid receptor subunit gamma-1 as ChEMBL target CHEMBL296, mapped to UniProt P23574. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Gamma-aminobutyric acid receptor subunit gamma-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P23574 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit gamma-1 |
| UniProt Accession | P23574 |
| Component Type | Protein |
| Sequence Length | 465 aa |
Gamma-aminobutyric acid receptor subunit gamma-1
Review this target as Gamma-aminobutyric acid receptor subunit gamma-1, mapped to UniProt P23574. Sequence length is 465 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL42464 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL12 | 8.3 | IC50 | 5.0 | Approved |
| CHEMBL273481 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL10450 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL96 | 7.48 | IC50 | 33.0 | Preclinical |
| CHEMBL10438 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL38835 | 7.14 | Kd | 72.2 | Preclinical |
| CHEMBL40804 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL296263 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL3138293 | 5.8 | IC50 | 1600.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 6 | 2 | 5.6 |
| cell membrane format | 3 | 6 | 7.1 |
| single protein format | 3 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 3 | 3 | 6.5 |
| tissue-based format | 3 | 2 | 7.5 |
| cell-based format | 2 | 0 | — |
| assay format | 1 | 0 | — |