Tyrosine-protein kinase JAK1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt P52332. Use UniProt P52332 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P52332 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase JAK1
Review this target as Tyrosine-protein kinase JAK1, mapped to UniProt P52332. Sequence length is 1153 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase JAK1 as ChEMBL target CHEMBL2968, mapped to UniProt P52332. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein kinase JAK1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P52332 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase JAK1 |
| UniProt Accession | P52332 |
| Component Type | Protein |
| Sequence Length | 1153 aa |
Tyrosine-protein kinase JAK1
Review this target as Tyrosine-protein kinase JAK1, mapped to UniProt P52332. Sequence length is 1153 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3622821 | 7.85 | IC50 | 14.0 | Approved |
| CHEMBL21156 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL3622826 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL5542400 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL5563563 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL221959 | 6.59 | IC50 | 258.0 | Approved |
| CHEMBL3116050 | 6.58 | IC50 | 260.0 | Preclinical |
| CHEMBL5566342 | 6.39 | IC50 | 408.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 13 | 8 | 7.0 |
| single protein format | 3 | 1 | 7.8 |