Arachidonate 5-lipoxygenase · SINGLE PROTEIN · Bos taurus
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As of 2026-09-13Protein identity stays anchored to UniProt Q9BEG3. Use UniProt Q9BEG3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9BEG3 as the stable identity anchor, then attach disease evidence before program review.
5-lipoxygenase
Review this target as Arachidonate 5-lipoxygenase, mapped to UniProt Q9BEG3. ChEMBL maps the protein component as 5-lipoxygenase. Sequence length is 430 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Arachidonate 5-lipoxygenase as ChEMBL target CHEMBL2980, mapped to UniProt Q9BEG3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Arachidonate 5-lipoxygenase |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | Q9BEG3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-lipoxygenase |
| UniProt Accession | Q9BEG3 |
| Component Type | Protein |
| Sequence Length | 430 aa |
5-lipoxygenase
Review this target as Arachidonate 5-lipoxygenase, mapped to UniProt Q9BEG3. ChEMBL maps the protein component as 5-lipoxygenase. Sequence length is 430 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL300982 | 6.75 | IC50 | 180.0 | Clinical |
| CHEMBL57062 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL56161 | 6.62 | IC50 | 240.0 | Preclinical |
| CHEMBL335405 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL133113 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL52 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL440508 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL133805 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL36648 | 6.3 | IC50 | 500.0 | Clinical |
| CHEMBL96598 | 6.3 | IC50 | 500.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 62 | 5.6 |
| single protein format | 3 | 21 | 5.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 62 | 5.2 |
| assay format | 1 | 17 | 5.5 |