Estrogen receptor beta · SINGLE PROTEIN · Mus musculus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O08537. Use UniProt O08537 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O08537 as the stable identity anchor, then attach disease evidence before program review.
Estrogen receptor beta
Review this target as Estrogen receptor beta, mapped to UniProt O08537. Sequence length is 530 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Estrogen receptor beta as ChEMBL target CHEMBL2995, mapped to UniProt O08537. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Estrogen receptor beta is the right protein anchor across sources, using UniProt O08537 as the stable mapping.
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| Preferred Name | Estrogen receptor beta |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O08537 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Estrogen receptor beta |
| UniProt Accession | O08537 |
| Component Type | Protein |
| Sequence Length | 530 aa |
Estrogen receptor beta
Review this target as Estrogen receptor beta, mapped to UniProt O08537. Sequence length is 530 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL188528 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL135 | 8.64 | IC50 | 2.3 | Approved |
| CHEMBL187207 | 8.57 | IC50 | 2.7 | Preclinical |
| CHEMBL450940 | 8.43 | IC50 | 3.7 | Clinical |
| CHEMBL186513 | 8.37 | IC50 | 4.3 | Preclinical |
| CHEMBL187673 | 8.02 | IC50 | 9.5 | Preclinical |
| CHEMBL187392 | 8.0 | IC50 | 9.9 | Preclinical |
| CHEMBL188882 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL188230 | 7.78 | IC50 | 16.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 0 | — |
| single protein format | 3 | 0 | — |
| assay format | 2 | 9 | 8.3 |