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Target Snapshot

CHEMBL2997 Target Snapshot

AMP deaminase 2 · SINGLE PROTEIN · Homo sapiens

68Compounds
4Assays
0Approved Drugs
90.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q01433. Use UniProt Q01433 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q01433 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats AMP deaminase 2 as ChEMBL target CHEMBL2997, mapped to UniProt Q01433. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
AMP deaminase 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2997
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q01433
AMP deaminase 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether AMP deaminase 2 is the right protein anchor across sources, using UniProt Q01433 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAMP deaminase 2
UniProt AccessionQ01433
Component TypeProtein
Sequence Length825 aa

AMP deaminase 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as AMP deaminase 2, mapped to UniProt Q01433. Sequence length is 825 aa.

Mapped IDQ01433
Review nameAMP deaminase 2
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5049.0
KI41.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5269095 7.52 IC50 30.0 Preclinical
CHEMBL5271711 7.22 IC50 60.0 Preclinical
CHEMBL5272816 7.0 IC50 100.0 Preclinical
CHEMBL5270167 6.96 IC50 110.0 Preclinical
CHEMBL5287644 6.89 IC50 130.0 Preclinical
CHEMBL5287535 6.85 IC50 140.0 Preclinical
CHEMBL5276735 6.77 IC50 170.0 Preclinical
CHEMBL5281489 6.77 IC50 170.0 Preclinical
CHEMBL5284620 6.75 IC50 180.0 Preclinical
CHEMBL5289502 6.72 IC50 190.0 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
20
5.5
11
6.0
15
6.5
2
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
60
Tested Compounds
1
Assay Types
Binding — 4 assays, 60 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 60 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine