Multidrug resistance-associated protein 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P33527. Use UniProt P33527 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P33527 as the stable identity anchor, then attach disease evidence before program review.
Multidrug resistance-associated protein 1
Review this target as Multidrug resistance-associated protein 1, mapped to UniProt P33527. Sequence length is 1531 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Multidrug resistance-associated protein 1 as ChEMBL target CHEMBL3004, mapped to UniProt P33527. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Multidrug resistance-associated protein 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P33527 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Multidrug resistance-associated protein 1 |
| UniProt Accession | P33527 |
| Component Type | Protein |
| Sequence Length | 1531 aa |
Multidrug resistance-associated protein 1
Review this target as Multidrug resistance-associated protein 1, mapped to UniProt P33527. Sequence length is 1531 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL58 | 8.82 | IC50 | 1.5 | Approved |
| CHEMBL28629 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL281496 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL26779 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL25903 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL26150 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL25905 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL29743 | 7.86 | IC50 | 13.7 | Preclinical |
| CHEMBL281326 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL418382 | 7.77 | IC50 | 17.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 238 | 346 | 5.4 |
| single protein format | 15 | 14 | 5.6 |
| assay format | 9 | 134 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 94 | 32 | 5.9 |
| cell membrane format | 65 | 26 | 5.8 |
| subcellular format | 4 | 0 | — |
| assay format | 2 | 0 | — |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 1 | 5.8 |
| mitochondrion format | 4 | 0 | — |
| assay format | 2 | 0 | — |
| cell membrane format | 2 | 0 | — |
| single protein format | 1 | 1 | 4.8 |