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Target Snapshot

CHEMBL3013 Target Snapshot

High affinity choline transporter 1 · SINGLE PROTEIN · Mus musculus

45Compounds
2Assays
1Approved Drugs
45.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q8BGY9. Use UniProt Q8BGY9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8BGY9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats High affinity choline transporter 1 as ChEMBL target CHEMBL3013, mapped to UniProt Q8BGY9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
High affinity choline transporter 1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3013
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8BGY9
High affinity choline transporter 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether High affinity choline transporter 1 is the right protein anchor across sources, using UniProt Q8BGY9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHigh affinity choline transporter 1
UniProt AccessionQ8BGY9
Component TypeProtein
Sequence Length580 aa

High affinity choline transporter 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as High affinity choline transporter 1, mapped to UniProt Q8BGY9. Sequence length is 580 aa.

Mapped IDQ8BGY9
Review nameHigh affinity choline transporter 1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC507.0
KI38.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1209654 7.7 Ki 20.04 Preclinical
CHEMBL1209507 7.3 Ki 50.0 Preclinical
CHEMBL1209508 7.05 Ki 90.01 Preclinical
CHEMBL1209577 6.74 Ki 180.3 Preclinical
CHEMBL1209578 6.7 Ki 200.45 Preclinical
CHEMBL1209579 6.64 Ki 230.14 Preclinical
CHEMBL1209581 6.28 Ki 521.19 Preclinical
CHEMBL1209713 6.19 Ki 640.03 Preclinical
CHEMBL282468 6.17 Ki 680.77 Approved
CHEMBL1209653 6.15 Ki 701.46 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
5
5.5
4
6.0
3
6.5
2
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CHOLINE CHLORIDE
CHEMBL282468
Approved 2012
Assay Landscape

Assay Landscape

2
Total Assays
44
Tested Compounds
1
Assay Types
Binding — 2 assays, 44 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 6 5.4
tissue-based format 1 38 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine