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Target Snapshot

CHEMBL3018 Target Snapshot

Suppressor of tumorigenicity 14 protein · SINGLE PROTEIN · Homo sapiens

557Compounds
93Assays
2Approved Drugs
586.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9Y5Y6. Use UniProt Q9Y5Y6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9Y5Y6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Suppressor of tumorigenicity 14 protein as ChEMBL target CHEMBL3018, mapped to UniProt Q9Y5Y6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Suppressor of tumorigenicity 14 protein
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3018
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9Y5Y6
Suppressor of tumorigenicity 14 protein
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Suppressor of tumorigenicity 14 protein is the right protein anchor across sources, using UniProt Q9Y5Y6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSuppressor of tumorigenicity 14 protein
UniProt AccessionQ9Y5Y6
Component TypeProtein
Sequence Length855 aa

Suppressor of tumorigenicity 14 protein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Suppressor of tumorigenicity 14 protein, mapped to UniProt Q9Y5Y6. Sequence length is 855 aa.

Mapped IDQ9Y5Y6
Review nameSuppressor of tumorigenicity 14 protein
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC5095.0
KI485.0
KD6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3916317 10.96 Ki 0.011 Preclinical
CHEMBL2086421 10.96 Ki 0.011 Preclinical
CHEMBL273264 10.7 Ki 0.02 Clinical
CHEMBL3354674 10.21 Ki 0.061 Preclinical
CHEMBL3655686 10.16 Ki 0.069 Preclinical
CHEMBL3289302 10.1 Ki 0.08 Preclinical
CHEMBL469090 10.1 Ki 0.08 Preclinical
CHEMBL2089123 10.06 Ki 0.088 Preclinical
CHEMBL3352840 10.04 Ki 0.092 Preclinical
CHEMBL5081575 9.89 IC50 0.13 Preclinical
Distribution

pChEMBL Value Distribution

25
5.0
46
5.5
70
6.0
65
6.5
93
7.0
81
7.5
71
8.0
29
8.5
25
9.0
8
9.5
pChEMBL
Assay Landscape

Assay Landscape

93
Total Assays
470
Tested Compounds
3
Assay Types
Binding — 88 assays, 470 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 49 348 7.2
cell-based format 30 26 6.5
assay format 9 96 7.4
ADME — 4 assays, 45 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 45 6.5
Functional — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 2 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine