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Target Snapshot

CHEMBL3027 Target Snapshot

Neurotensin receptor type 1 · SINGLE PROTEIN · Rattus norvegicus

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114Compounds
33Assays
0Approved Drugs
84.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P20789. Use UniProt P20789 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P20789 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neurotensin receptor type 1 as ChEMBL target CHEMBL3027, mapped to UniProt P20789. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neurotensin receptor type 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3027
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P20789
Neurotensin receptor type 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neurotensin receptor type 1 is the right protein anchor across sources, using UniProt P20789 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNeurotensin receptor type 1
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP20789
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeurotensin receptor type 1
UniProt AccessionP20789
Component TypeProtein
Sequence Length424 aa

Neurotensin receptor type 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Neurotensin receptor type 1, mapped to UniProt P20789. Sequence length is 424 aa.

Mapped IDP20789
Review nameNeurotensin receptor type 1
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Phase III
Assay Mix

Activity Type Distribution

IC5015.0
KI54.0
EC5011.0
KD4.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL342252 11.0 EC50 0.01 Preclinical
CHEMBL407196 10.4 EC50 0.04 Preclinical
CHEMBL407196 8.96 Ki 1.1 Preclinical
CHEMBL415788 8.9 EC50 1.27 Preclinical
CHEMBL3040381 8.85 Ki 1.4 Preclinical
CHEMBL3622802 8.85 EC50 1.41 Preclinical
CHEMBL506981 8.59 Ki 2.6 Clinical
CHEMBL1793839 8.3 IC50 5.0 Preclinical
CHEMBL2371276 8.1 IC50 8.0 Preclinical
CHEMBL342252 8.0 IC50 10.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
11
5.5
11
6.0
12
6.5
6
7.0
5
7.5
3
8.0
7
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

33
Total Assays
53
Tested Compounds
2
Assay Types
Binding — 21 assays, 53 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 7 11 6.4
single protein format 7 27 6.3
cell-based format 6 12 7.1
tissue-based format 1 3 8.5
Functional — 12 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 3 9.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine