Cathepsin K · SINGLE PROTEIN · Rattus norvegicus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O35186. Use UniProt O35186 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O35186 as the stable identity anchor, then attach disease evidence before program review.
Cathepsin K
Review this target as Cathepsin K, mapped to UniProt O35186. Sequence length is 329 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cathepsin K as ChEMBL target CHEMBL3034, mapped to UniProt O35186. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cathepsin K is the right protein anchor across sources, using UniProt O35186 as the stable mapping.
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| Preferred Name | Cathepsin K |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | O35186 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cathepsin K |
| UniProt Accession | O35186 |
| Component Type | Protein |
| Sequence Length | 329 aa |
Cathepsin K
Review this target as Cathepsin K, mapped to UniProt O35186. Sequence length is 329 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL191558 | 10.14 | Ki | 0.072 | Preclinical |
| CHEMBL154579 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL284939 | 8.32 | Ki | 4.8 | Preclinical |
| CHEMBL154959 | 8.26 | IC50 | 5.5 | Preclinical |
| CHEMBL203665 | 8.1 | Ki | 8.0 | Clinical |
| CHEMBL156764 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL249965 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL345982 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL154862 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL84691 | 7.7 | IC50 | 20.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 28 | 6.9 |
| cell-based format | 1 | 6 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 0 | — |