AMPK alpha1/beta2/gamma1 · PROTEIN COMPLEX · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O43741. Use UniProt O43741 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O43741 as the stable identity anchor, then attach disease evidence before program review.
5'-AMP-activated protein kinase subunit beta-2
Review this target as AMPK alpha1/beta2/gamma1, mapped to UniProt O43741. ChEMBL maps the protein component as 5'-AMP-activated protein kinase subunit beta-2. Sequence length is 272 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats AMPK alpha1/beta2/gamma1 as ChEMBL target CHEMBL3038453, mapped to UniProt O43741. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether AMPK alpha1/beta2/gamma1 is the right protein anchor across sources, using UniProt O43741 as the stable mapping.
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| Preferred Name | AMPK alpha1/beta2/gamma1 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | O43741 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5'-AMP-activated protein kinase subunit beta-2 |
| UniProt Accession | O43741 |
| Component Type | Protein |
| Sequence Length | 272 aa |
5'-AMP-activated protein kinase subunit beta-2
Review this target as AMPK alpha1/beta2/gamma1, mapped to UniProt O43741. ChEMBL maps the protein component as 5'-AMP-activated protein kinase subunit beta-2. Sequence length is 272 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3957286 | 8.4 | EC50 | 4.0 | Preclinical |
| CHEMBL5438171 | 7.45 | IC50 | 35.6 | Preclinical |
| CHEMBL4082745 | 7.4 | EC50 | 40.0 | Preclinical |
| CHEMBL5428147 | 7.15 | IC50 | 70.8 | Preclinical |
| CHEMBL5412961 | 6.58 | IC50 | 263.2 | Preclinical |
| CHEMBL5396179 | 6.28 | IC50 | 531.2 | Preclinical |
| CHEMBL5404502 | 6.24 | IC50 | 582.2 | Preclinical |
| CHEMBL5397288 | 6.19 | IC50 | 648.7 | Preclinical |
| CHEMBL5401167 | 6.18 | IC50 | 658.6 | Preclinical |
| CHEMBL5415699 | 6.11 | IC50 | 772.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 3 | 6.9 |
| protein complex format | 9 | 13 | 6.3 |
| assay format | 3 | 0 | — |