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Target Snapshot

CHEMBL3038469 Target Snapshot

CDK2/Cyclin A2 · PROTEIN COMPLEX · Homo sapiens

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2,208Compounds
366Assays
4Approved Drugs
1,849.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P24941. Use UniProt P24941 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P24941 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CDK2/Cyclin A2 as ChEMBL target CHEMBL3038469, mapped to UniProt P24941. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CDK2/Cyclin A2
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3038469
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P24941
Cyclin-dependent kinase 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CDK2/Cyclin A2 is the right protein anchor across sources, using UniProt P24941 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCDK2/Cyclin A2
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP24941
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCyclin-dependent kinase 2
UniProt AccessionP24941
Component TypeProtein
Sequence Length298 aa

Cyclin-dependent kinase 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CDK2/Cyclin A2, mapped to UniProt P24941. ChEMBL maps the protein component as Cyclin-dependent kinase 2. Sequence length is 298 aa.

Mapped IDP24941
Review nameCDK2/Cyclin A2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
2
Phase III
10
Phase II
7
Phase I
Assay Mix

Activity Type Distribution

IC501,611.0
KI185.0
KD53.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5808524 9.8 IC50 0.16 Preclinical
CHEMBL261720 9.7 IC50 0.2 Preclinical
CHEMBL388978 9.4 IC50 0.4 Preclinical
CHEMBL5837976 9.4 IC50 0.4 Preclinical
CHEMBL5739950 9.22 IC50 0.6 Preclinical
CHEMBL14762 9.15 IC50 0.7 Clinical
CHEMBL4590821 9.15 IC50 0.7 Preclinical
CHEMBL4848734 9.15 IC50 0.7 Preclinical
CHEMBL5803114 9.15 IC50 0.7 Preclinical
CHEMBL2377864 9.05 IC50 0.9 Preclinical
Distribution

pChEMBL Value Distribution

179
5.0
155
5.5
255
6.0
191
6.5
216
7.0
114
7.5
65
8.0
34
8.5
19
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

ABEMACICLIB
CHEMBL3301610
Approved 2017
Properties Compare Identifier
PALBOCICLIB
CHEMBL189963
Approved 2015
Properties Compare Identifier
Assay Landscape

Assay Landscape

366
Total Assays
1,178
Tested Compounds
2
Assay Types
Binding — 359 assays, 1,178 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 277 908 6.4
cell-based format 42 122 6.4
assay format 40 148 6.6
ADME — 7 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 5 9 6.8
cell-based format 2 18 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine