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Target Snapshot

CHEMBL3038474 Target Snapshot

CDK8/Cyclin C · PROTEIN COMPLEX · Homo sapiens

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1,085Compounds
160Assays
2Approved Drugs
774.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P49336. Use UniProt P49336 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P49336 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CDK8/Cyclin C as ChEMBL target CHEMBL3038474, mapped to UniProt P49336. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CDK8/Cyclin C
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3038474
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P49336
Cyclin-dependent kinase 8
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CDK8/Cyclin C is the right protein anchor across sources, using UniProt P49336 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCDK8/Cyclin C
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP49336
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCyclin-dependent kinase 8
UniProt AccessionP49336
Component TypeProtein
Sequence Length464 aa

Cyclin-dependent kinase 8

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CDK8/Cyclin C, mapped to UniProt P49336. ChEMBL maps the protein component as Cyclin-dependent kinase 8. Sequence length is 464 aa.

Mapped IDP49336
Review nameCDK8/Cyclin C
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
3
Phase I
Assay Mix

Activity Type Distribution

IC50702.0
KI66.0
KD6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4789125 9.72 IC50 0.191 Preclinical
CHEMBL4078454 9.7 IC50 0.2 Preclinical
CHEMBL4789603 9.58 IC50 0.262 Preclinical
CHEMBL4776812 9.56 IC50 0.278 Preclinical
CHEMBL4777356 9.5 IC50 0.314 Preclinical
CHEMBL4083552 9.47 IC50 0.34 Preclinical
CHEMBL5435821 9.43 IC50 0.37 Preclinical
CHEMBL4096487 9.4 IC50 0.4 Preclinical
CHEMBL5409410 9.4 IC50 0.4 Preclinical
CHEMBL5434183 9.4 IC50 0.4 Preclinical
Distribution

pChEMBL Value Distribution

25
5.0
26
5.5
47
6.0
81
6.5
107
7.0
126
7.5
141
8.0
91
8.5
35
9.0
5
9.5
pChEMBL
Approved Drugs

Approved Drugs

SORAFENIB
CHEMBL1336
Approved 2005
Properties Compare Identifier
Assay Landscape

Assay Landscape

160
Total Assays
664
Tested Compounds
1
Assay Types
Binding — 160 assays, 664 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 89 404 7.6
assay format 37 255 7.7
cell-based format 34 5 7.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine