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Target Snapshot

CHEMBL3038482 Target Snapshot

DNA gyrase · PROTEIN COMPLEX · Staphylococcus aureus

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852Compounds
123Assays
5Approved Drugs
787.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

DNA gyrase shows approved-linked disease relevance led by impetigo. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P0A0K8. Start with impetigo, then reuse UniProt P0A0K8 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with impetigo, then reuse UniProt P0A0K8 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
impetigo

DNA gyrase shows approved-linked disease relevance led by impetigo. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with impetigo because it currently carries approved-linked support. Linked drugs include OZENOXACIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats DNA gyrase as ChEMBL target CHEMBL3038482, mapped to UniProt P0A0K8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
DNA gyrase
PROTEIN COMPLEX · Staphylococcus aureus
As of 2026-09-14
ChEMBL target ID
CHEMBL3038482
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0A0K8
DNA gyrase subunit B
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether DNA gyrase is the right protein anchor across sources, using UniProt P0A0K8 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why impetigo is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameDNA gyrase
Target TypePROTEIN COMPLEX
OrganismStaphylococcus aureus
UniProtP0A0K8
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDNA gyrase subunit B
UniProt AccessionP0A0K8
Component TypeProtein
Sequence Length644 aa

DNA gyrase subunit B

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as DNA gyrase, mapped to UniProt P0A0K8. ChEMBL maps the protein component as DNA gyrase subunit B. Sequence length is 644 aa.

Mapped IDP0A0K8
Review nameDNA gyrase
OrganismStaphylococcus aureus
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

DNA gyrase shows approved-linked disease relevance led by impetigo. 4 more disease programs remain visible in the same review block.

Approved-linked Approved
impetigo
1 linked drug · 1 direct · 1 efficacy
Linked drugOZENOXACIN
Clinical signal Phase II
infectious otitis media
1 linked drug · 1 direct · 1 efficacy
Linked drugFINAFLOXACIN
Clinical signal Phase II
injury
1 linked drug · 1 direct · 1 efficacy
Linked drugOZENOXACIN
Clinical signal Phase II
Otitis media
1 linked drug · 1 direct · 1 efficacy
Linked drugFINAFLOXACIN
Clinical signal Phase II
urinary tract infection
1 linked drug · 1 direct · 1 efficacy
Linked drugFINAFLOXACIN
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with impetigo because it currently carries approved-linked support. Linked drugs include OZENOXACIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseimpetigo
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

5
Approved
2
Phase III
Assay Mix

Activity Type Distribution

IC50761.0
KI26.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL36506 9.19 IC50 0.65 Approved
CHEMBL4854181 9.1 IC50 0.8 Preclinical
CHEMBL5288212 8.91 IC50 1.22 Preclinical
CHEMBL4126667 8.73 IC50 1.86 Preclinical
CHEMBL4126781 8.73 IC50 1.86 Preclinical
CHEMBL4127899 8.73 IC50 1.86 Preclinical
CHEMBL4127930 8.73 IC50 1.86 Preclinical
CHEMBL4127938 8.73 IC50 1.86 Preclinical
CHEMBL4128711 8.73 IC50 1.86 Preclinical
CHEMBL4129139 8.73 IC50 1.86 Preclinical
Distribution

pChEMBL Value Distribution

70
5.0
75
5.5
49
6.0
72
6.5
47
7.0
45
7.5
47
8.0
9
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NOVOBIOCIN
CHEMBL36506
Approved 1964
Properties Compare Identifier
Assay Landscape

Assay Landscape

123
Total Assays
485
Tested Compounds
2
Assay Types
Binding — 116 assays, 485 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 111 432 6.2
assay format 5 53 6.6
Functional — 7 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 5 0 —
organism-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine