JAK3/JAK1 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P52333. Use UniProt P52333 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P52333 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase JAK3
Review this target as JAK3/JAK1, mapped to UniProt P52333. ChEMBL maps the protein component as Tyrosine-protein kinase JAK3. Sequence length is 1124 aa.
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This review treats JAK3/JAK1 as ChEMBL target CHEMBL3038491, mapped to UniProt P52333. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | JAK3/JAK1 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P52333 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase JAK3 |
| UniProt Accession | P52333 |
| Component Type | Protein |
| Sequence Length | 1124 aa |
Tyrosine-protein kinase JAK3
Review this target as JAK3/JAK1, mapped to UniProt P52333. ChEMBL maps the protein component as Tyrosine-protein kinase JAK3. Sequence length is 1124 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3622821 | 8.7 | IC50 | 2.0 | Approved |
| CHEMBL4588333 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL2105759 | 8.3 | IC50 | 5.0 | Approved |
| CHEMBL221959 | 8.17 | IC50 | 6.7 | Approved |
| CHEMBL4439418 | 8.15 | IC50 | 7.1 | Preclinical |
| CHEMBL4635876 | 8.1 | IC50 | 7.943 | Preclinical |
| CHEMBL5209379 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL5170161 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL4297507 | 8.05 | IC50 | 9.0 | Clinical |
| CHEMBL4437638 | 8.03 | IC50 | 9.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 53 | 132 | 7.0 |
| protein complex format | 12 | 67 | 6.8 |
| tissue-based format | 9 | 35 | 6.0 |
| assay format | 2 | 1 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 8 | 5 | 5.7 |