JAK2/JAK1 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P23458. Use UniProt P23458 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P23458 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase JAK1
Review this target as JAK2/JAK1, mapped to UniProt P23458. ChEMBL maps the protein component as Tyrosine-protein kinase JAK1. Sequence length is 1154 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats JAK2/JAK1 as ChEMBL target CHEMBL3038492, mapped to UniProt P23458. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | JAK2/JAK1 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P23458 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase JAK1 |
| UniProt Accession | P23458 |
| Component Type | Protein |
| Sequence Length | 1154 aa |
Tyrosine-protein kinase JAK1
Review this target as JAK2/JAK1, mapped to UniProt P23458. ChEMBL maps the protein component as Tyrosine-protein kinase JAK1. Sequence length is 1154 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3622821 | 8.52 | IC50 | 3.0 | Approved |
| CHEMBL5422886 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL4297507 | 7.6 | IC50 | 25.0 | Clinical |
| CHEMBL1789941 | 7.51 | IC50 | 31.0 | Approved |
| CHEMBL5409953 | 7.43 | IC50 | 37.0 | Preclinical |
| CHEMBL5396554 | 7.36 | IC50 | 44.0 | Preclinical |
| CHEMBL5404574 | 7.35 | IC50 | 45.0 | Preclinical |
| CHEMBL5407260 | 7.32 | IC50 | 48.0 | Preclinical |
| CHEMBL221959 | 7.29 | IC50 | 51.0 | Approved |
| CHEMBL5412967 | 7.24 | IC50 | 58.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 36 | 33 | 6.5 |
| protein complex format | 8 | 21 | 6.0 |
| tissue-based format | 5 | 1 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 3 | 6.5 |
| tissue-based format | 1 | 1 | 5.7 |