TAK1/TAB1 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q15750. Use UniProt Q15750 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q15750 as the stable identity anchor, then attach disease evidence before program review.
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Review this target as TAK1/TAB1, mapped to UniProt Q15750. ChEMBL maps the protein component as TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. Sequence length is 504 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats TAK1/TAB1 as ChEMBL target CHEMBL3038499, mapped to UniProt Q15750. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether TAK1/TAB1 is the right protein anchor across sources, using UniProt Q15750 as the stable mapping.
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| Preferred Name | TAK1/TAB1 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q15750 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
| UniProt Accession | Q15750 |
| Component Type | Protein |
| Sequence Length | 504 aa |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Review this target as TAK1/TAB1, mapped to UniProt Q15750. ChEMBL maps the protein component as TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. Sequence length is 504 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4796239 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL3953067 | 8.51 | IC50 | 3.1 | Preclinical |
| CHEMBL2407759 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL3916326 | 8.37 | IC50 | 4.3 | Preclinical |
| CHEMBL3924740 | 8.36 | IC50 | 4.4 | Preclinical |
| CHEMBL4752978 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL3919781 | 8.28 | IC50 | 5.2 | Preclinical |
| CHEMBL3917140 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL1077979 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL3823303 | 8.1 | IC50 | 8.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 26 | 98 | 6.1 |
| assay format | 11 | 70 | 6.6 |
| cell-based format | 3 | 0 | — |