PI3K p110 beta/p85 alpha · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P27986. Use UniProt P27986 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P27986 as the stable identity anchor, then attach disease evidence before program review.
Phosphatidylinositol 3-kinase regulatory subunit alpha
Review this target as PI3K p110 beta/p85 alpha, mapped to UniProt P27986. ChEMBL maps the protein component as Phosphatidylinositol 3-kinase regulatory subunit alpha. Sequence length is 724 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats PI3K p110 beta/p85 alpha as ChEMBL target CHEMBL3038510, mapped to UniProt P27986. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | PI3K p110 beta/p85 alpha |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P27986 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphatidylinositol 3-kinase regulatory subunit alpha |
| UniProt Accession | P27986 |
| Component Type | Protein |
| Sequence Length | 724 aa |
Phosphatidylinositol 3-kinase regulatory subunit alpha
Review this target as PI3K p110 beta/p85 alpha, mapped to UniProt P27986. ChEMBL maps the protein component as Phosphatidylinositol 3-kinase regulatory subunit alpha. Sequence length is 724 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4878958 | 9.51 | Ki | 0.31 | Preclinical |
| CHEMBL4531499 | 9.47 | IC50 | 0.34 | Preclinical |
| CHEMBL4860369 | 9.43 | Ki | 0.37 | Preclinical |
| CHEMBL1236962 | 9.28 | Ki | 0.53 | Clinical |
| CHEMBL4527563 | 9.27 | IC50 | 0.54 | Preclinical |
| CHEMBL4440406 | 9.24 | IC50 | 0.58 | Preclinical |
| CHEMBL4071605 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL4081433 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL4100135 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL4450219 | 9.15 | IC50 | 0.7 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 53 | 159 | 7.0 |
| cell-based format | 26 | 192 | 6.9 |
| assay format | 4 | 6 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 95 | 6.0 |
| assay format | 2 | 1 | 5.9 |
| protein complex format | 2 | 9 | 5.3 |