Tankyrase 1/2 · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Tankyrase 1/2 shows clinical signal disease relevance led by ovarian cancer. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9H2K2. Start with ovarian cancer, then reuse UniProt Q9H2K2 as the stable protein anchor across project notes and exports.
Start with ovarian cancer, then reuse UniProt Q9H2K2 as the stable protein anchor across project notes and exports.
Tankyrase 1/2 shows clinical signal disease relevance led by ovarian cancer. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with ovarian cancer because it currently carries clinical signal support. Linked drugs include 2X-121. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyPoly [ADP-ribose] polymerase tankyrase-2
Review this target as Tankyrase 1/2, mapped to UniProt Q9H2K2. ChEMBL maps the protein component as Poly [ADP-ribose] polymerase tankyrase-2. Sequence length is 1166 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tankyrase 1/2 as ChEMBL target CHEMBL3038515, mapped to UniProt Q9H2K2. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Tankyrase 1/2 is the right protein anchor across sources, using UniProt Q9H2K2 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why ovarian cancer is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Tankyrase 1/2 |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | Q9H2K2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Poly [ADP-ribose] polymerase tankyrase-2 |
| UniProt Accession | Q9H2K2 |
| Component Type | Protein |
| Sequence Length | 1166 aa |
Poly [ADP-ribose] polymerase tankyrase-2
Review this target as Tankyrase 1/2, mapped to UniProt Q9H2K2. ChEMBL maps the protein component as Poly [ADP-ribose] polymerase tankyrase-2. Sequence length is 1166 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tankyrase 1/2 shows clinical signal disease relevance led by ovarian cancer. 2 more disease programs remain visible in the same review block.
Start review with ovarian cancer because it currently carries clinical signal support. Linked drugs include 2X-121. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4646640 | 10.32 | IC50 | 0.048 | Preclinical |
| CHEMBL4442053 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4446044 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4539435 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4553990 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4572668 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4470218 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4470270 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4532667 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4585076 | 9.7 | IC50 | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 51 | 194 | 7.2 |
| protein format | 4 | 4 | 7.5 |
| assay format | 1 | 1 | 6.7 |