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Target Snapshot

CHEMBL3050 Target Snapshot

Amine oxidase [flavin-containing] B · SINGLE PROTEIN · Mus musculus

280Compounds
27Assays
1Approved Drugs
38.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q8BW75. Use UniProt Q8BW75 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8BW75 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Amine oxidase [flavin-containing] B as ChEMBL target CHEMBL3050, mapped to UniProt Q8BW75. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Amine oxidase [flavin-containing] B
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL3050
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q8BW75
Amine oxidase [flavin-containing] B
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Amine oxidase [flavin-containing] B is the right protein anchor across sources, using UniProt Q8BW75 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAmine oxidase [flavin-containing] B
UniProt AccessionQ8BW75
Component TypeProtein
Sequence Length520 aa

Amine oxidase [flavin-containing] B

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Amine oxidase [flavin-containing] B, mapped to UniProt Q8BW75. Sequence length is 520 aa.

Mapped IDQ8BW75
Review nameAmine oxidase [flavin-containing] B
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC5022.0
KI16.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5196906 9.4 IC50 0.4 Preclinical
CHEMBL26138 7.0 Ki 100.0 Preclinical
CHEMBL1950682 6.58 Ki 260.0 Preclinical
CHEMBL4453259 6.1 IC50 800.0 Preclinical
CHEMBL1950684 5.93 Ki 1180.0 Preclinical
CHEMBL42965 5.89 Ki 1300.0 Preclinical
CHEMBL1950683 5.79 Ki 1630.0 Preclinical
CHEMBL1950680 5.56 Ki 2770.0 Preclinical
CHEMBL1950686 5.54 Ki 2870.0 Preclinical
CHEMBL1950688 5.53 Ki 2950.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
8
5.5
1
6.0
1
6.5
1
7.0
0
7.5
0
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

27
Total Assays
23
Tested Compounds
2
Assay Types
Binding — 18 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 9 17 5.3
tissue-based format 5 2 7.0
single protein format 4 4 5.5
Functional — 9 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 6 0
assay format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine