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Target Snapshot

CHEMBL3063 Target Snapshot

Chymotrypsinogen B · SINGLE PROTEIN · Bos taurus

23Compounds
2Assays
0Approved Drugs
20.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P00767. Use UniProt P00767 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00767 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Chymotrypsinogen B as ChEMBL target CHEMBL3063, mapped to UniProt P00767. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Chymotrypsinogen B
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL3063
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P00767
Chymotrypsinogen B
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Chymotrypsinogen B is the right protein anchor across sources, using UniProt P00767 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelChymotrypsinogen B
UniProt AccessionP00767
Component TypeProtein
Sequence Length245 aa

Chymotrypsinogen B

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Chymotrypsinogen B, mapped to UniProt P00767. Sequence length is 245 aa.

Mapped IDP00767
Review nameChymotrypsinogen B
OrganismBos taurus
Assay Mix

Activity Type Distribution

IC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL108294 8.8 IC50 1.6 Preclinical
CHEMBL108540 8.68 IC50 2.1 Preclinical
CHEMBL111705 7.07 IC50 86.0 Preclinical
CHEMBL320132 6.64 IC50 230.0 Preclinical
CHEMBL445116 6.6 IC50 250.0 Preclinical
CHEMBL109236 6.0 IC50 1000.0 Preclinical
CHEMBL110995 5.96 IC50 1100.0 Preclinical
CHEMBL108931 5.82 IC50 1500.0 Preclinical
CHEMBL320750 5.66 IC50 2200.0 Preclinical
CHEMBL109291 5.47 IC50 3400.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
3
5.5
1
6.0
2
6.5
1
7.0
0
7.5
1
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
18
Tested Compounds
1
Assay Types
Binding — 2 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 18 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine