Neuronal acetylcholine receptor subunit alpha-3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P32297. Use UniProt P32297 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P32297 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit alpha-3
Review this target as Neuronal acetylcholine receptor subunit alpha-3, mapped to UniProt P32297. Sequence length is 505 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor subunit alpha-3 as ChEMBL target CHEMBL3068, mapped to UniProt P32297. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Neuronal acetylcholine receptor subunit alpha-3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P32297 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit alpha-3 |
| UniProt Accession | P32297 |
| Component Type | Protein |
| Sequence Length | 505 aa |
Neuronal acetylcholine receptor subunit alpha-3
Review this target as Neuronal acetylcholine receptor subunit alpha-3, mapped to UniProt P32297. Sequence length is 505 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6623 | 8.15 | EC50 | 7.0 | Preclinical |
| CHEMBL309804 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL365956 | 7.81 | IC50 | 15.6 | Preclinical |
| CHEMBL3 | 7.35 | IC50 | 45.0 | Approved |
| CHEMBL430497 | 6.89 | EC50 | 130.0 | Clinical |
| CHEMBL2270633 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL3 | 6.66 | Ki | 220.0 | Approved |
| CHEMBL334860 | 6.3 | EC50 | 500.0 | Preclinical |
| CHEMBL59986 | 6.16 | EC50 | 700.0 | Preclinical |
| CHEMBL1210515 | 6.0 | IC50 | 1000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 14 | 5.9 |
| single protein format | 3 | 2 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 15 | 5.8 |