DNA gyrase subunit B · SINGLE PROTEIN · Mycobacterium smegmatis
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P0C559. Use UniProt P0C559 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0C559 as the stable identity anchor, then attach disease evidence before program review.
DNA gyrase subunit B
Review this target as DNA gyrase subunit B, mapped to UniProt P0C559. Sequence length is 675 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA gyrase subunit B as ChEMBL target CHEMBL3085613, mapped to UniProt P0C559. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA gyrase subunit B is the right protein anchor across sources, using UniProt P0C559 as the stable mapping.
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| Preferred Name | DNA gyrase subunit B |
| Target Type | SINGLE PROTEIN |
| Organism | Mycobacterium smegmatis |
| UniProt | P0C559 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA gyrase subunit B |
| UniProt Accession | P0C559 |
| Component Type | Protein |
| Sequence Length | 675 aa |
DNA gyrase subunit B
Review this target as DNA gyrase subunit B, mapped to UniProt P0C559. Sequence length is 675 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3263615 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3263621 | 8.66 | IC50 | 2.2 | Preclinical |
| CHEMBL3114208 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL3263619 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL3263620 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3259858 | 8.43 | IC50 | 3.7 | Preclinical |
| CHEMBL3114202 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL3263613 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL3263616 | 8.34 | IC50 | 4.6 | Preclinical |
| CHEMBL3114206 | 8.3 | IC50 | 5.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 23 | 126 | 6.4 |
| cell-based format | 5 | 146 | 4.8 |
| assay format | 3 | 5 | 5.0 |